Buy human menopausal gonadotropin

This highly purified HMG for research is a specialized gonadotropin preparation that provides both Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) activity. Human Menopausal Gonadotropin has been a foundational tool in reproductive science for decades. Unlike single recombinant hormones, HMG offers the unique advantage of delivering a balanced, synergistic stimulation of the gonadal axis, making it an invaluable tool for specific research models.

As of 2025, the standards for biological reagents are exceptionally high. Our HMG is subject to extensive purification processes to create a “highly purified” (HP-HMG) product, minimizing extraneous urinary proteins and ensuring high specific activity and consistency. This product is intended strictly for in-vitro and laboratory research applications by qualified professionals in endocrinology and reproductive biology.

The Dual-Action Advantage of Highly Purified HMG for Research

The primary utility of HMG lies in its composition as a combined gonadotropin. This allows researchers to study the coordinated effects of both LH and FSH, which is often more physiologically relevant than studying either hormone in isolation.

A Balanced Combination: LH and FSH Activity

Our highly purified HMG for research is standardized to contain a 1:1 ratio of FSH and LH bioactivity, providing a complete stimulation of the gonadal steroidogenic pathways.

FSH Activity: The Follicle-Stimulating Hormone component acts on the FSH receptors. In female models, this stimulates the growth and maturation of ovarian follicles by acting on granulosa cells. In male models, it acts on the Sertoli cells of the testes, which is essential for spermatogenesis.

LH Activity: The Luteinizing Hormone component acts on LH receptors. In female models, this stimulates theca cells surrounding the follicles to produce androgens, which are then converted to estrogen by the FSH-stimulated granulosa cells. It is also the trigger for ovulation. In male models, it acts on the Leydig cells to stimulate the production of testosterone.

Key Applications in Reproductive Science

This dual-action makes our highly purified HMG for research an ideal reagent for a variety of studies:

Ovarian Stimulation Models: It is the classic agent for inducing multifollicular development in animal models used to study the mechanisms of controlled ovarian hyperstimulation (COH) for assisted reproductive technology (ART) research.

Hypogonadism Research: An essential tool for preclinical models of hypogonadotropic hypogonadism, allowing scientists to investigate the restoration of gonadal function and fertility through combined gonadotropin replacement.

Spermatogenesis Studies: Used to research the complex hormonal interplay required to initiate and maintain sperm production in models where the hypothalamic-pituitary-gonadal axis is suppressed.

The Importance of High Purification

Since HMG is a biologically derived product, purity is paramount for reliable research. Our product undergoes rigorous multi-step purification, including advanced chromatographic techniques, to:

• Remove the vast majority of non-gonadotropic urinary proteins.
• Ensure high specific activity of both LH and FSH.
• Provide a consistent, reliable product from batch to batch.

IMPORTANT LEGAL DISCLAIMER: This product is intended for laboratory research purposes ONLY. It is not for human or veterinary use. It is a chemical preparation and not a medication. It must not be used for human fertility treatments or any other therapeutic application. It must be handled by qualified professionals in a controlled laboratory setting.

 

FAQs (Frequently Asked Questions)

What is HMG (Human Menopausal Gonadotropin)?

HMG is a hormonal preparation containing a combination of gonadotropins, specifically Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), typically in a 1:1 ratio. It is used in research to stimulate the gonads (ovaries or testes).

What is the difference between HMG, HCG, and recombinant FSH?

HMG contains both LH and FSH activity. HCG (Human Chorionic Gonadotropin) primarily mimics the action of LH only, but with a much longer half-life. Recombinant FSH (like Gonal-F® or Follistim® in the clinical world) provides only FSH activity. HMG is unique in providing a balanced combination of both LH and FSH.

Why is a “highly purified” HMG important for research?

Because HMG is derived from a biological source (urine), older preparations contained many extraneous proteins. A “highly purified” (HP) version has undergone extensive purification to remove these contaminants, resulting in a product with higher specific activity and greater purity, which is essential for obtaining reliable and reproducible research data.

What is the typical ratio of LH to FSH in your highly purified HMG for research?

Our highly purified HMG for research is standardized to a 1:1 ratio of LH bioactivity to FSH bioactivity, providing a balanced and consistent stimulus for your experiments.

What are the storage and reconstitution protocols for this product?

The lyophilized (freeze-dried) HMG should be stored in a refrigerator at 2-8°C. After reconstitution with the provided sterile diluent or sterile water, it should be used immediately and not stored for future use unless specific protocols are followed.

Is this product intended for human fertility treatments?

Absolutely not. This is a chemical preparation sold strictly for in-vitro and laboratory research. It is not a sterile, pharmaceutical-grade product approved by any regulatory agency for human use and must not be used for fertility treatments or any other clinical application.

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