This high-purity Hexarelin peptide is a powerful and multifaceted tool for the scientific community, offering unique avenues of investigation in both endocrinology and cardiovascular science. Hexarelin is a synthetic hexapeptide and a member of the growth hormone-releasing peptide (GHRP) family. It is structurally similar to GHRP-6 but engineered for significantly greater potency in stimulating the release of endogenous growth hormone (GH).
As of 2025, the body of research has distinguished Hexarelin from other secretagogues due to its dual action: it is not only a powerful agonist of the ghrelin receptor but also interacts with other receptors, such as CD36, which has opened up exciting preclinical research into its potential cardioprotective effects. This product is intended strictly for in-vitro and laboratory research, providing scientists with a reliable compound to explore these distinct and significant biological pathways.
The Dual Research Potential of Our High-Purity Hexarelin Peptide
The value of Hexarelin in a research setting is twofold, making it a uniquely versatile compound. Our commitment to >99% purity ensures that researchers can confidently attribute observed effects to the peptide itself, whether studying the pituitary-adrenal axis or cardiac cell function.
Potent Stimulation of the GH Axis
The primary and most well-known function of our high-purity Hexarelin peptide is its potent stimulation of GH release.
- Ghrelin Receptor Agonism: Hexarelin is a powerful agonist for the growth hormone secretagogue receptor (GHSR-1a), also known as the ghrelin receptor. It initiates a stronger intracellular signal than its predecessors, leading to a more robust and intense pulse of GH from the pituitary somatotrophs.
- Research Considerations: Due to its high potency, a key area of study with Hexarelin is the phenomenon of pituitary desensitization. Researchers use it to investigate the mechanisms of receptor downregulation and to model the effects of intense, pulsatile GH release.
A Unique Avenue for Cardioprotective Research
Perhaps the most exciting and unique aspect of Hexarelin is its documented effects on the cardiovascular system, which appear to be independent of its GH-releasing properties.
- GH-Independent Action: Preclinical studies have shown that Hexarelin can offer cardioprotective effects in models of myocardial ischemia and cardiac stunning.
- CD36 Receptor Interaction: This unique action is believed to be mediated, at least in part, by its interaction with the CD36 receptor, which is involved in fatty acid uptake and inflammation in cardiac cells. This makes our high-purity Hexarelin peptide an invaluable tool for cardiologists and cell biologists studying novel pathways for protecting the heart.
Purity and Quality for Complex Studies
Given Hexarelin’s dual mechanisms of action, absolute purity is non-negotiable for valid research.
- Advanced Synthesis: Our Hexarelin is synthesized using state-of-the-art methods to ensure the correct six-amino-acid sequence.
- HPLC and Mass Spec Verification: Every batch is rigorously tested using HPLC to guarantee >99% purity and confirmed with Mass Spectrometry to verify its identity and molecular weight.
- Lyophilization: The final product is lyophilized to create a stable powder, ensuring its integrity and a long shelf-life for your research needs.
IMPORTANT LEGAL DISCLAIMER: This product is intended for laboratory research purposes ONLY. It is not for human or veterinary use. It is not a drug, food, or cosmetic and is not intended to diagnose, treat, cure, or prevent any disease. It must be handled only by qualified professionals in a controlled research setting.
FAQs (Frequently Asked Questions)
What is Hexarelin?
Hexarelin is a synthetic, six-amino-acid peptide that belongs to the growth hormone-releasing peptide (GHRP) family. It is one of the most potent known synthetic stimulators of endogenous growth hormone release and is also studied for its unique cardioprotective properties.
How does Hexarelin differ from other GHRPs like GHRP-2?
Hexarelin is significantly more potent at stimulating GH release than GHRP-2 or GHRP-6. However, this potency can also lead to more pronounced desensitization of the pituitary over time and a greater increase in cortisol and prolactin levels. Its main distinguishing feature is its GH-independent cardioprotective effects, which are not a primary characteristic of other GHRPs.
What is the significance of Hexarelin in cardiovascular research?
Hexarelin is unique among GHRPs because it has been shown in preclinical studies to protect cardiac tissue, likely through its interaction with the CD36 receptor. This makes it a valuable tool for researching new ways to protect the heart from injury.
What is the purity of your high-purity Hexarelin peptide?
Our Hexarelin peptide is guaranteed to have a purity level exceeding 99%. This is verified for every batch using High-Performance Liquid Chromatography (HPLC), and a Certificate of Analysis (COA) is available.
What is the amino acid sequence of Hexarelin?
The amino acid sequence for Hexarelin is L-Histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide, often abbreviated as His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2.
Is this product intended for human use?
Absolutely not. This product is a chemical intended strictly for in-vitro and laboratory research. It is not approved for any human or veterinary application and is not a medication or supplement.
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