Buy MOTS-c

This mitochondrial peptide MOTS-c is a groundbreaking tool for scientists investigating the frontiers of metabolism, aging, and exercise physiology. The discovery of MOTS-c represents a paradigm shift in cell biology, revealing that mitochondria are not just cellular powerhouses but also dynamic signaling organelles that communicate their functional state to the rest of the cell. Unlike virtually all other signaling peptides, which are encoded in the nuclear genome, MOTS-c is encoded within the mitochondrial DNA, making it a true “mitokine.”

As of 2025, MOTS-c is a central focus of research for its potent effects on systemic metabolism and its role as an “exercise mimetic.” Our high-purity, synthetic MOTS-c provides a reliable and consistent reagent for scientists to explore the vast potential of this novel signaling pathway. This product is intended strictly for in-vitro and laboratory research applications.

Harnessing the Power of the Mitochondria with Our Mitochondrial Peptide MOTS-c

The unique origin and powerful function of MOTS-c make it one of the most exciting research peptides available. Our commitment to >99% purity ensures that researchers can study its effects with the highest degree of confidence and reproducibility.

Mechanism of Action: The AMPK Activator and Exercise Mimetic

The primary mechanism of action for our mitochondrial peptide MOTS-c is its ability to regulate cellular energy at a fundamental level.

AMPK Activation: MOTS-c has been shown to be a potent activator of AMP-activated protein kinase (AMPK). AMPK is the master energy sensor of the cell; it is activated during times of low energy (like exercise) and orchestrates a switch from energy storage to energy production and consumption.

Mimicking Exercise: By activating AMPK, MOTS-c initiates the same beneficial metabolic cascades that are triggered by physical exercise. In research models, this includes increased glucose uptake into muscle cells, enhanced fatty acid oxidation (fat burning), and improved overall insulin sensitivity. This is why it is extensively studied as an “exercise mimetic.”

Key Research Applications

The potent metabolic effects of our mitochondrial peptide MOTS-c make it an essential tool for:

Metabolic Disease Research: Investigating novel therapeutic strategies for insulin resistance, type 2 diabetes, and obesity in preclinical models. Its ability to improve glucose handling independent of traditional insulin pathways is a major area of interest.

Gerontology & Longevity: As mitochondrial function declines with age, MOTS-c is a key tool for studying the reversal of age-related metabolic dysfunction and sarcopenia. Researchers are exploring its potential to enhance physical performance and promote a healthier lifespan in aging models.

Exercise Physiology: Allowing scientists to dissect the specific molecular pathways that underlie the health benefits of exercise, and to study how these pathways can be pharmacologically targeted.

Purity and Quality for Cutting-Edge Research

High-Fidelity Synthesis: Precisely synthesizing the 16-amino acid sequence of MOTS-c.

HPLC Purification: Purifying every batch to a standard of >99% to ensure the highest quality and bioactivity.

Mass Spectrometry Verification: Confirming the correct molecular weight and identity of the final product.

Lyophilization: Supplying the peptide in a stable, freeze-dried powder for maximum shelf-life.

IMPORTANT LEGAL DISCLAIMER: This product is intended for laboratory research purposes ONLY. It is not for human or veterinary use. It is not a drug, dietary supplement, or cosmetic and is not intended to diagnose, treat, cure, or prevent any disease. It must be handled only by qualified professionals in a controlled research setting.

FAQs (Frequently Asked Questions)

What is MOTS-c?

It is a 16-amino acid peptide that is uniquely encoded by the mitochondrial genome. It acts as a signaling molecule (a “mitokine”) that helps regulate cellular energy, metabolism, and insulin sensitivity throughout the body.

What is a “mitochondrial-derived peptide,” and why is that significant?

It means the genetic code for MOTS-c is located in the DNA of the mitochondria, not the cell’s nucleus like most proteins and peptides. This is significant because it represents a new form of biological communication, where the mitochondria can directly signal their status and influence the function of the entire organism.

What does it mean that MOTS-c is an “exercise mimetic” in a research context?

In research models, MOTS-c has been shown to activate the same molecular pathways (like AMPK) and produce many of the same metabolic benefits (like improved glucose uptake and fat burning) as physical exercise. It is therefore studied as a compound that “mimics” the effects of exercise at a cellular level.

What is the purity of your mitochondrial peptide MOTS-c?

Our mitochondrial peptide MOTS-c is guaranteed to have a purity level exceeding 99%, as verified by High-Performance Liquid Chromatography (HPLC) for every batch. A Certificate of Analysis is available.

What is the amino acid sequence?

The amino acid sequence is Met-Ala-Pro-Arg-Gln-Leu-Phe-Ala-Leu-Leu-Val-Ser-Gln-Arg-Arg-Lys.

Is this product intended for human use to treat diabetes or as an exercise substitute?

Absolutely not. This product is a chemical compound sold strictly for in-vitro and laboratory research to study metabolic pathways. It is not an approved drug or medical treatment and must not be used on humans or animals for any therapeutic purpose.

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