Buy MGF

This PEG-MGF for muscle repair research provides scientists with a powerful tool to investigate the body’s own localized mechanisms for tissue regeneration. Mechano Growth Factor (MGF) is a unique splice variant of the Insulin-like Growth Factor 1 (IGF-1) gene. Unlike the systemic, liver-derived form of IGF-1, MGF is expressed locally in tissues like muscle in direct response to mechanical stress or damage. It acts as the primary signal to initiate the repair process.

However, the native MGF peptide has an extremely short half-life, making it unsuitable for most research applications. Our product is PEG-MGF, a form where the MGF peptide is covalently bonded to a Polyethylene Glycol (PEG) molecule. This process, known as pegylation, dramatically increases the peptide’s stability and circulation time, transforming it into a robust and reliable tool for laboratory research.

The Power of Satellite Cell Activation with PEG-MGF for Muscle Repair Research

The primary value of MGF lies in its specific and potent effect on the muscle stem cell population, known as satellite cells. Our high-purity PEG-MGF allows for the sustained study of this critical regenerative pathway.

Mechanism of Action: The Satellite Cell Proliferator

The core function of our PEG-MGF for muscle repair research is to mimic the body’s natural first response to muscle injury.

Initiation of Myogenesis: Upon binding to IGF-1 receptors on quiescent (dormant) satellite cells nestled alongside muscle fibers, MGF provides a powerful stimulus for these cells to become activated and begin to proliferate (multiply).

Fueling Repair and Growth: This expanded pool of satellite cells is the raw material for muscle repair. The cells can then differentiate and fuse with existing damaged muscle fibers to repair them, or fuse together to create new myofibers, contributing to muscle hypertrophy.

The Critical Advantage of Pegylation

The native MGF peptide is degraded in minutes. Our PEG-MGF solves this problem.

Enhanced Stability: The PEG molecule acts as a protective shield, preventing the peptide from being rapidly broken down by enzymes in the body.

Extended Half-Life: This shielding effect increases the peptide’s half-life from a few minutes to many hours, allowing for a sustained biological effect after administration in research models. This stability is essential for obtaining reliable and meaningful data.

Key Research Applications

Myology & Sarcopenia: The definitive tool for studying the role of satellite cell activation in muscle hypertrophy and, critically, for investigating potential strategies to combat age-related muscle wasting (sarcopenia) by re-awakening dormant stem cells.

Cardiology: Used in preclinical models to investigate MGF’s potential to promote the repair of cardiac muscle tissue following an ischemic event (heart attack).

Neuroscience: Exploring the documented neuroprotective effects of MGF in various models of neuronal damage and disease.

IMPORTANT LEGAL DISCLAIMER: This product is intended for laboratory research purposes ONLY. It is not for human or veterinary use. It is a research chemical and not a drug, dietary supplement, or cosmetic. Its use for personal muscle building, therapy, or any application outside of a controlled laboratory setting is strictly prohibited.

 

FAQs (Frequently Asked Questions)

What is MGF (Mechano Growth Factor)?

MGF is a splice variant of the IGF-1 gene that is produced locally in muscle tissue in response to damage or stress. Its primary natural role is to stimulate muscle stem cells (satellite cells) to begin the repair process.

What is PEG-MGF, and why is it pegylated?

PEG-MGF is Mechano Growth Factor attached to a Polyethylene Glycol (PEG) molecule. This process, “pegylation,” is essential because native MGF has a half-life of only a few minutes, making it impractical for research. Pegylation protects the peptide from degradation, extending its half-life to many hours and making it a stable and effective research tool.

How does MGF’s mechanism for muscle repair differ from IGF-1 LR3?

While both are related to IGF-1, they have different primary roles. MGF is considered the initial “proliferator,” acting locally to rapidly multiply the pool of satellite cells needed for repair. IGF-1 LR3 is a more systemic and sustained “differentiator,” promoting the growth and fusion of these and other cells, contributing to overall anabolism. MGF is the spark for repair; IGF-1 is the fuel for growth.

What is the purity of your PEG-MGF for muscle repair research?

Our PEG-MGF for muscle repair research is guaranteed to have a purity of greater than 98%, as verified by High-Performance Liquid Chromatography (HPLC) for every batch. A Certificate of Analysis is available.

What are the main areas of research for PEG-MGF?

The primary research areas are muscle repair and growth (myology), age-related muscle loss (sarcopenia), cardiac tissue repair, and its neuroprotective effects in neuroscience.

Is this product intended for human muscle growth or therapy?

Absolutely not. This product is a chemical compound sold strictly for in-vitro and laboratory research. It is not an approved drug or medical treatment and must not be used on humans or animals for bodybuilding or therapeutic purposes.

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