Buy Kisspeptin

This GnRH-releasing Kisspeptin-10 is a foundational tool for any scientist investigating the complex interplay of hormones that govern reproduction. The discovery of the Kisspeptin system was a landmark moment in science, identifying the “missing link” that initiates the entire cascade of puberty and maintains fertility. This product is a high-purity, synthetic version of the most active fragment, Kisspeptin-10, designed to give researchers direct access to this master control switch.

By providing a reliable and potent agonist of the KISS1 receptor, we empower researchers to precisely stimulate and study the body’s GnRH pulse generator. This peptide is synthesized to the highest standards of quality and is intended strictly for in-vitro and laboratory research applications.

The Power of a Direct GnRH-Releasing Stimulus

The primary value of Kisspeptin-10 in a research setting is its direct and powerful action at the very top of the reproductive axis. Our GnRH-releasing Kisspeptin-10 allows for the precise study of this crucial biological event.

Mechanism of Action: The Master Switch for GnRH Neurons

The singular function of Kisspeptin-10 that makes it so valuable is its role as the primary excitatory signal for GnRH neurons.

Direct Stimulation: Kisspeptin-10 binds to its receptor, KISS1R (GPR54), located on the surface of GnRH neurons in the hypothalamus.

Triggering the Pulse: This binding event causes a strong depolarization, leading to the synthesis and pulsatile secretion of GnRH. It is this pulsatile pattern that is essential for proper pituitary function.

Upstream Control: By acting at this high level, Kisspeptin-10 allows researchers to bypass downstream variables and study the health and responsiveness of the GnRH system itself.

Key Applications for a GnRH-Releasing Peptide

The ability to reliably trigger a GnRH pulse makes our GnRH-releasing Kisspeptin-10 essential for studies in:

• Neuroendocrinology: Investigating the neural circuits that control the GnRH pulse generator and how they are affected by factors like stress, metabolism, and circadian rhythms.
• Developmental Biology: Modeling the onset of puberty and understanding the precise sequence of events that activates the reproductive axis for the first time.
• Reproductive Disorders: Probing the cause of conditions like hypogonadotropic hypogonadism to determine if the issue originates with dysfunctional GnRH neurons.

Purity and Quality for Foundational Research

High-Fidelity Synthesis: Precisely recreating the 10-amino acid sequence.

HPLC Purification: Purifying every batch to a standard of >99% to ensure the highest quality.

Mass Spectrometry Verification: Confirming the correct molecular weight and identity of the final product.

Lyophilization: Supplying the peptide in a stable, freeze-dried powder for maximum shelf-life.

IMPORTANT LEGAL DISCLAIMER: This product is intended for laboratory research purposes ONLY. It is not for human or veterinary use. It is not a drug, dietary supplement, or cosmetic and is not intended to diagnose, treat, cure, or prevent any disease. It must be handled only by qualified professionals in a controlled research setting.

 

FAQs (Frequently Asked Questions)

What makes it a “GnRH-releasing peptide”?

Kisspeptin-10’s primary biological function is to bind to its receptors on GnRH neurons in the hypothalamus. This action directly stimulates those neurons to produce and release Gonadotropin-Releasing Hormone (GnRH), making it the natural, upstream “GnRH-releasing peptide.”

How does studying with it differ from studying with GnRH itself?

Studying with Kisspeptin-10 allows researchers to investigate the health and function of the GnRH neurons themselves. It helps answer the question, “Can the GnRH system be properly stimulated?” Studying with GnRH bypasses this step and only tests the pituitary’s response.

Is it the only peptide that releases GnRH?

While other neurotransmitters can influence GnRH neurons, Kisspeptin is considered the most potent and essential positive regulator. Its signaling is absolutely required for puberty and fertility, making it the “master regulator.”

What is the purity of your GnRH-releasing Kisspeptin-10?

Our GnRH-releasing Kisspeptin-10 is guaranteed to have a purity level exceeding 99%, as verified by High-Performance Liquid Chromatography (HPLC) for every batch. A Certificate of Analysis is available.

What is the amino acid sequence of Kisspeptin-10?

The amino acid sequence is Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (YNWNSFGLRF-NH2).

Is this product intended for human use?

Absolutely not. This product is a chemical intended strictly for in-vitro and laboratory research. It is not approved for any human or veterinary application and is not a medication or supplement.

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