Buy IGF-1 LR3 peptide

This long-acting IGF-1 LR3 peptide is a powerful research tool designed for scientists in cell biology, endocrinology, and metabolic research. Insulin-like Growth Factor 1 (IGF-1) is the primary mediator of Growth Hormone’s effects and a crucial factor in cellular growth, proliferation, and differentiation. However, the bioactivity of native IGF-1 in vivo and in vitro is tightly regulated and limited by its high affinity for a family of IGF-binding proteins (IGFBPs).

IGF-1 LR3 is a synthetically modified analogue of IGF-1, engineered to overcome this limitation. Its enhanced stability and prolonged bioactivity make it a superior reagent for a wide range of applications, from promoting survival in serum-free cell cultures to studying the sustained effects of IGF-1 signaling in preclinical models. This product is produced via recombinant DNA technology to the highest standards of purity and is intended strictly for laboratory research.The Superior Bioactivity of Our Long-Acting IGF-1 LR3 Peptide

The key advantage of IGF-1 LR3 lies in its intelligent molecular design, which translates to significantly enhanced potency and a longer duration of action compared to its native counterpart.

Mechanism of Action: Evading the IGFBPs

The superior performance of our long-acting IGF-1 LR3 peptide is due to two specific structural modifications:

N-Terminal Extension: A 13-amino acid extension has been added to its N-terminus.

R3 Substitution: A Glutamic Acid at the third position has been replaced with an Arginine.Together, these changes dramatically reduce the affinity of IGF-1 LR3 for the various IGFBPs. This means that more of the peptide remains “free” and biologically active in solution, able to bind to the IGF-1 receptor on target cells and exert its effects for a much longer period.Key Applications in Cell Culture

This enhanced stability makes IGF-1 LR3 an exceptional and cost-effective supplement for cell culture media, particularly in serum-free or low-serum conditions. Researchers utilize it to:

Promote Cell Proliferation and Viability: A small concentration can significantly enhance the growth and survival of a wide range of cell types.

Induce Differentiation: Study the effects of sustained IGF-1 signaling on cellular differentiation pathways.

Increase Recombinant Protein Production: Enhance the productivity of cell lines used in biopharmaceutical manufacturing research.

Advanced Research in Anabolism and Metabolism

The potent, sustained action of our long-acting IGF-1 LR3 peptide makes it an ideal tool for investigating:

Muscle Growth (Myogenesis): Studying its powerful effects on the proliferation and fusion of satellite cells (muscle stem cells), which is critical for muscle repair and growth (hypertrophy and hyperplasia).

Glucose Metabolism: Investigating its insulin-like effects, such as stimulating glucose uptake in peripheral tissues.

Guaranteed Quality and Purity

Recombinant Production: Produced in a robust E. coli expression system for high yield and consistency.

High Purity: Chromatographically purified to >95%, as confirmed by HPLC analysis.

Verified Identity: The correct 83-amino acid sequence and molecular weight are confirmed with Mass Spectrometry.

Lyophilized for Stability: Shipped as a freeze-dried powder to ensure maximum stability and shelf-life.

IMPORTANT LEGAL DISCLAIMER: This product is intended for laboratory and research purposes ONLY. It is not for human or veterinary use. It is a research chemical and not a drug, dietary supplement, or cosmetic. Its use in any application outside of a controlled laboratory setting is strictly prohibited. The purchase of this product constitutes an agreement to use it for its intended research purposes only, in full compliance with all applicable laws and regulations.

 

FAQs (Frequently Asked Questions)

What is IGF-1 LR3?

IGF-1 LR3 is a modified, long-acting analogue of Insulin-like Growth Factor 1 (IGF-1). It has been altered to have a much lower affinity for IGF-binding proteins, which makes it significantly more potent and stable than native IGF-1 in a research setting.

What is the primary advantage of IGF-1 LR3 over standard IGF-1 for research?

The primary advantage is its extended half-life and greater bioactivity. Because it doesn’t get “mopped up” by binding proteins as quickly, it remains active in cell culture media or in vivo for much longer, providing a more sustained and potent stimulus to the IGF-1 receptors.

What are the main applications for this peptide in a laboratory setting?

Its most common applications are as a potent supplement in serum-free cell culture media to promote cell growth and survival, and in preclinical research to study anabolic processes like muscle growth (myogenesis) and cellular regeneration.

What is the purity of your long-acting IGF-1 LR3 peptide?

Our long-acting IGF-1 LR3 peptide is guaranteed to have a purity of greater than 95%, as verified by High-Performance Liquid Chromatography (HPLC) for every batch. A Certificate of Analysis is available.

How should this protein be handled and stored?

The lyophilized (freeze-dried) powder should be stored long-term at -20°C. After reconstitution with sterile, slightly acidic water (e.g., 0.1 M acetic acid) to improve solubility, the solution should be aliquoted to avoid freeze-thaw cycles and can be stored at 2-8°C for the short term or -20°C for the long term.

Is this product intended for human use or bodybuilding?

Absolutely not. This product is a powerful research chemical sold strictly for in-vitro and laboratory experimentation. It is not approved for any human or veterinary use. Its use for personal bodybuilding or performance enhancement is dangerous, illegal in many regions, and strictly prohibited.

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